The aim of the present investigation was to develop oral dispersible films (ODFs) of Granisetran hydrochloride and to investigate the effect of the formulation variable plasticizer on the physic-chemical properties and on the dissolution profile of formulated ODFs. Hydroxypropyl methyl cellulose (HPMC- 50cps) was used as a film former and Poly ethylene glycol (PEG 4000), propylene glycol (PG), sorbitol, glycerin were used as plasticizers. The bioavailability of Granisetron HCl is only 65% indicating extensive first pass metabolism in liver which is an ideal feature for developing ODFs. Hence, the present investigation was undertaken with the objective of formulating ODFs of Granisetran HCl using different plasticizers (Glycerol, PEG, PG, Sorbitol) and to made it potentially useful for treatment of nausea and vomiting and to enhance the convenience and compliance of the elderly and pediatric patients. % drug release profile was found to alter with different plasticizers used and best release profile was observed in case of ODFs with glycerin as plasticizer with around 97% drug release in third minute.
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